Paper Information

Title: 

THE EFFECT OF L-ARGININE ON SPATIAL MEMORY OF OVARIECTOMIZED RATS IN MORRIS WATER MAZE

Type: POSTER
Author(s): SAFAARZADEH FATEMEH*,ESLAMIZADEH M.J.,NEMATI KARIMAVI H.A.,HAJZADEH M.A.R.,KHAZAEI MOHAMMAD,HOSSEINI MAHMOUD
 
 *DEPT. OF PHYSIOLOGY, SCHOOL OF MEDICINE, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Introduction: The role of ovarian hormones and nitric oxide on learning and memory and their interaction have been widely investigated. The present study carried out to evaluate the effect of L-arginine on spatial memory of ovariectomized (OVX) and sham operated rats in Morris Water Maze.
Materials and Methods: Forty two rats were divided into six groups: 1) Sham, 2) OVX, 3) Sham-LA-A, 4) OVX-LA-A 5) Sham-LA-C, and 6) OVX-LA-C. The animals of sham-LA-A and OVX-LA-A were acutely treated by 500 mg/kg/day of L-arginine during 5 test days. Sham-LAC and OVX-LA-C chronically received 500 mg/kg/day every day during 8 weeks before 5 test days. The animals of Sham and OVX groups received 1ml/kg saline instead of L-arginine. Finally, the animals of all groups were tested in Morris Water Maze. The escape latency and traveled path to reach the platform were compared between groups. p<0.05 was considered significant.
Results: Time latency and path length in OVX group were significantly higher than sham group (p<0.05). The animals of OVX-LA-A group had significantly lower traveled path length and time latency compared to OVX group (p<0.001). Chronic treatment by L-arginine didn't have significant effect on OVX and sham operated animals.
Discussion: The results showed that acute but not chronic administration of L-arginine improved spatial memory of OVX rats, however, it didn’t have effect on sham operated rats. It might be concluded that the presence of ovarian hormones is necessary for the effect of NO but it needs to be more investigated.

 
Keyword(s): SPATIAL MEMORY, OVARIECTOMY, L-ARGININE, MORRIS WATER MAZE
 
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