Paper Information

Title: 

USUAL DOSES OF MORPHINE ON RETENTION OF MEMORY FORMED IN MORRIS WATER MAZE IN WISTAR RAT

Type: POSTER
Author(s): SADEGH A.*,FEREYDOUNI MASOUD,MOGHIMI ALI,KAVOUSI Z.
 
 *DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCE, FERDOWSI UNIVERSITY OF MASHHAD, MASHHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Different studies indicate positive or negative effects of morphine on learning and memory processes in rodents. There are several reports, which indicate the presence of opioidergic pathways and receptors in rat’s hippocampus that play a role in learning and memory processes. This research was done to survey the effects of acute administration of ultra low and usual doses of morphine on retention of formed memory
Male adult wistar rats (200-250g) were used (n=7) in four groups: sham control, morphine at ultra low doses of 1μg/kg and 100μg/kg and at usual dose of 10mg/kg. The evaluation of memory was done in morris water maze (mwm). The animals were trained during four days (4trials per day). Doses of morphine were injected intraperitoneally in 5th day and after thirty minutes; the time spent in target quadrant was measured as a parameter of memory retention assessment.
Acute administration of morphine at the doses of 10mg/kg (p<0.001) and 1μg/kg (p<0.05) impaired the ability of retention, while 100μg/kg of morphine had no significant effect. Opioidergic receptors couple with gi/go proteins, which induced inhibitory effects and inhibit neurotransmitter release. Maybe it is the mechanism underlying the effect of morphine on impairing the memory retention. There is a similarity between the effects of morphine at doses of 10mg/kg and 1μg/kg, which needs to discuss and study more.

 
Keyword(s): MEMORY RETENTION, ULTRA LOW DOSES OF MORPHINE, MORRIS WATER MAZE
 
Yearly Visit 7   tarjomyar
 
Latest on Blog
Enter SID Blog