Paper Information

Title: 

EVALUATION THE EFFECT OF AQUA EXTRACTION OF CANNABIS SATIVA SEED ON SPATIAL MEMORY CONSOLIDATION IN MORRIS WATER MAZE

Type: POSTER
Author(s): KAFAEI RAZAVI MORTEZA*,EBRAHIMIPOUR SAEIDEH,TEHRANIPOUR M.,BEHNAM RASOULI MORTEZA
 
 *DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCE, ISLAMIC AZAD UNIVERSITY, MASHHAD BRANCH, MASHHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

As the point of physiology, memory form from changes in the conducting message. These changes cause to formation of long-term potentiation. Cannabis sativa have more than 61 components that have named Cannabinoid. Thus the aim of this study is evaluation the effect of aqua extraction Cannabis sativa seed on the spatial memory of extraction of Cannabis sativa seed on spatial memory consolidation in Rats. First numbers of 40 Rats (3-4 mounth, 320-260g) were divided into 4experimental groups and control group. Cannabis sativa seed was extracted with Soxhelet apparatus. Spatial memory was scaled with Morris water maze (7 days, 4 trails).experimental groups with 50mg.kg-1, 100mg.kg-1, 150mg.kg-1, 210mg.kg-1 were injected in the Abdomen (IP) orderly. After memory consolidation platform area was changed and MWM was done (5 days, 4 trails). The result show that experimental groups with 50mg.kg-1, 100mg.kg-1, 150mg.kg-1 doses for learning time have significant level deduction in the comparison of control group (p<0.05), but experimental group with 210mg/kg dose has not significant level in the comparison of control group (p<0.05). This LTP probably was done with DSI and DSE mechanisms in the CA1 area of Hippocampus that with neurotransmitter regulation cause to neuroplasticity.

 
Keyword(s): CANNABIS SATIVA, LTP, SPATIAL MEMORY, MWM
 
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