Paper Information

Title: 

THE EFFECT OF INTRA HIPPOCAMPAL (CA1) NMDA RECEPTOR AGONIST AND CONSUMPTION OF ZNCL2 ON PASSIVE AVOIDANCE LEARNING AND MEMORY IN ADULT MALE RATS

Type: POSTER
Author(s): VALIZADEH SOHEILA,MOAZEDI A.A.,RAFIEIRAD M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Zinc is an essential trace element that plays an important role in synaptic plasticity and modulating the activity of CNS and involve in learning and memory. Zinc in synaptic vesicle in the hippocampus area exerting modulatory effects on NMDA glutamate receptor.
In this experiment the effects of NMDA agonist administration intra hippocampus on passive avoidance learning and memory in adult male rats in presence and absence of ZnCl2 by step down task has been investigated. Animal divided into 9 group (n=8). Control group, second group received 0.1μg/rat NMDA in 1μlit saline for 4 days. Sham group received saline in the same volume. Six remain groups received 30, 100mg/kg/day ZnCl2 in drinking water for 2 weeks. Fourth and fifth groups only received 30, 100mg/kg/day ZnCl2, but others groups (9, 8, 7, 6) in addition consumption zncl2 received drug and saline in the same condition to 2, 3 groups.
Our experiment showed that consumption of 30, 100mg/kg/day ZnCl2 impair learning and memory in adult male rats (P<0.05), while administration of NMDA improve the impairment effects on zncl2 consumption (P<0.05) It seems that zinc effects on passive avoidance learning and memory by effects on subunits of NMDA receptor in hippocampus.

 
Keyword(s): ZINC CHLORIDE, HIPPOCAMPUS, PASSIVE AVOIDANCE LEARNING, STEP DOWN
 
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