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Paper Information

Title: 

POSTNATAL ZINC SUPPLEMENTATION IMPAIRS THE SPATIAL LEARNING AND MEMORY IN MALE RATS

Type: POSTER
Author(s): GHAEMI FATEMEH*,TALAEI ZAVAREH S.A.R.,DAVARI S.,TAGHIZADEH MOHSEN,SALAMI MOHSEN
 
 *PHYSIOLOGY RESEARCH CENTER, KASHAN UNIVERSITY OF MEDICAL SCIENCES, KASHAN, I.R. IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Zinc act as neuromodulator in mammal's CNS. It is revealed that, zinc enhancement in serum may impair the spatial memory. This research examined the effect of zinc supplementation in pre- and postnatal periods on spatial learning and memory in young adult male rats. Three Groups of 50d male Wistar rats (n=10 for each) were tested in the Morris Water Maze for spatial learning and memory in 5 consecutive days; GS1 rats are fed with 227 mg/L zinc sulfate in drinking water (ad libitum) from 21d of age for 30 days, GS2 animals that their mother fed with supplement in drinking water during pregnancy and lactation, and, there was control group with normal diet and water. Our results showed that, in spite of increased serum zinc levels in both supplemented groups, GS1 rats were found to have impairments in spatial learning and memory. They were significantly slower to find a stationary platform and on memory retrieval test they spent less time in the target quadrant. These data show that, postnatal but not prenatal zinc supplementation can lead to impairments in spatial learning and memory.

 
Keyword(s): ZINC SUPPLEMENT, SPATIAL LEARNING, MORRIS WATER MAZE, RAT
 
 
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