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Paper Information

Title: 

INTERACTION OF LIGHT AND MELATONIN RECEPTORS ON SPATIAL LEARNING AND MEMORY OF RATS

Type: POSTER
Author(s): SALAMI MAHMOUD*,TALAEI ZAVAREH S.A.R.,HAMIDI GH.A.
 
 *RESEARCH CENTER OF PHYSIOLOGY, KASHAN UNIVERSITY OF MEDICAL SCIENCES, KASHAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Melatonin is a dark related hormone and its production is pronouncedly affected by changes in circadian rhythm. Plenty evidences demonstrate that melatonin influences learning and memory. The present study uncovers the role of melatonin receptors as well as light exposure on spatial learning andmemory. Sixty male rats at the age of 45 postnatal days were used. The animals were assigned in six groups: Control animals (CO) reared in 12hrlight-dark conditions; Light reared animals (LR) kept in constant light from birth through testing; two groups of CO and DR animals treated by melatonin, and another two groups injected by the melatonin receptor antagonist luzindole. Delay in finding the platform of the Morris water maze as well as distance passed from releasing point to platform were measured for evaluating learning and memory capabilities.
All tested groups displayed a noticeable improvement in the acquisition phase of the experiment. Melatonin treated rats made more failures that the others. While luzindole improved behavior of the LR animals it deterioratesthe task learning the CO rats. Differences were not significant between behavior of the untreated CO and LR subjects in the probe test. The agonist and antagonist weaken recalling of the learned task in the CO and DR groups.
Constant exposure to light and melatonin weaken the spatial learning in rats. Why luzindole differently affects the maze searching in the CO and LR groups may contributed to light exposure alternations in melatonin receptors.

 
Keyword(s): SENSORY EXPERIENCE, MELATONIN, LUZINDOLE, SPATIAL MEMORY, RAT, MORRIS WATER MAZE
 
 
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