Paper Information

Title: 

STAPHYLOCOCCAL SCALDED SKIN SYNDROME IN A NEONATE WITH LEUKOCYTE ADHESION DEFICIENCY (LAD); A CASE REPORT

Type: PAPER
Author(s): MOHAMMADI M.,FATHI P.,CHAVOSHZADEH Z.
 
 
 
Name of Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Type of Seminar:  CONGRESS
Sponsor:  IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES
Date:  2007Volume 6
 
 
Abstract: 

Leukocyte adhesion deficiency (LAD) is a rare autosomal recessive disorder of leukocyte function. These patients usually present with recurrent severe infections, impaired pus formation, and impaired wound healing. Patients with the severe phenotype characteristically have delayed umbilical stump separation (more than 30 days).
The reported case was a 3 days old girl, admitting with poor condition and massive bullous and ulcerative skin lesions, progressing to necrotizing and scaling skin lesions .Blood culture was positive for staphylococcus aureus. The neonate responded to broad spectrum antibiotics.
Umbilical stump has not separated till 30 days and, in spite of infection treatment, the patients CBC showed hyperleukocytosis. According to these finding, LAD was suspected and with measuring CD11 and CD18 and decreased markers, the case was confirmed.
We recommend in neonates with dermal infective lesions together with hyperleukocytosis and stump separation delay, we must consider immune deficiencies, like LAD.

 
Keyword(s): LEUKOCYTE ADHESION DEFICIENCY ( LAD ), DERMAL STAPHYLOCOCCAL LESIONS
 
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