Paper Information

Title: 

EFFECT OF CANNABINOIDERGIC DRUGS IN THE DORSAL HIPPOCAMPUS OF PHYSOSTIGMINE SENSITIZED RATS IN THE MEMORY FORMATION

Type: POSTER
Author(s): PIRI MORTEZA*,ORYAN SHAHRBANOU
 
 *DEPARTMENT OF BIOLOGY, FACULTY OF BASIC SCIENCES, AZAD UNIVERSITY, TEHRAN SCIENCES AND RESEARCHES BRANCH, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

In present study, the effects of intra-dorsal hippocampal (intra-CA1) injection of cannabinoid receptor agents on memory formation have been investigated in 5-days physositigmine-treated rats. Passive avoidance task of memory has been used to examine for retrieval of memory formation, 24 h after training. Physositigmine was injected subcutaneously (S.C.), once daily for 5-days followed by 10 days free of the nicotine before training. Post-training intra-CA1 administration of cannabinoid receptor agonist, WIN55, 212-2 (0.25 and 0.5μg/rat) and CB1 receptor antagonist, AM251 (25 and 50ng/rat, intra–CA1) decreased memory retrieval. Repeated administration of different doses of physostigmine (0.12, 0.25 and 0.5 mg/kg) for 5-days has no effect on memory retrieval. However, repeated administration of different doses of physostigmine (0.12, 0.25 and 0.5 mg/kg) for 5-days reversed amnesia induced by WIN55, 212-2 or AM251. The results suggest that WIN55, 212-2 influence on memory formation and subchronic physostigmine pre-treatment may restore memory through a possible cholinergic receptor sensitization.

 
Keyword(s): CANNABINOIDS, PHYSOSTIGMINE, DORSAL HIPPOCAMPUS, SENSITIZATION, PASSIVE AVOIDANCE LEARNING
 
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