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Paper Information

Title: 

INFLUENCE OF INTRACEREBRAL ADMINISTRATION OF NO AGENTS IN DORSAL HIPPOCAMPUS (CA1) ON CANNABINOID STATE-DEPENDENT MEMORY IN THE STEP-DOWN PASSIVE AVOIDANCE TEST

Type: POSTER
Author(s): PIRI MORTEZA*,NASEHI M.,ZARINDAST M.R.
 
 *DEPARTMENT OF BIOLOGY, FACULTY OF BASIC SCIENCES, AZAD UNIVERSITY, ARDABILE BRANCH, ARDABILE, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

The present study, the effects of nitric oxide agents on WIN55, 212-2 induced state dependent memory of passive avoidance task were examined in mice. One-trial step down paradigm was used for the assessment of memory retention in adult male NMRI mice. Post-training intra-CA1 administration of CB1 and CB2 receptor agonist, WIN55, 212-2 (0.25, 0.5 and 1μg/mouse), dose-dependently decreased the memory retrieval. The memory impairment induced by post-training administration of WIN55, 212-2 (1μg/mouse) was restored by pre-test administration of the same dose of the drug (1μg/mouse, intra-CA1), showing the state-dependent memory of WIN55, 212-2. Single intra-CA1 administration of L-arginine (0.3, 1 and 3μg/mouse) or L-NAME (0.3, 1 and 3μg/mouse), 5 min pre-test could not alter memory retrieval. On the other hand, in the animals in which retrieval was impaired due to post-training administration of WIN55, 212-2 (1μg/mouse), pre-test intra-CA1 administration of Larginine (1 and 3μg/mouse), but not L-NAME (0.3, 1 and 3μg/mouse) 24 hr after training restored memory retrieval. Also, in the animal which received both post training (1μg/mouse) and pre-test injection of WIN55, 212-2 (1μg/mouse), the injection of L-NAME (3μg/mouse, intra-CA1), 2 min before pre-test administration decreased retrieval. Furthermore, in the animals under influence of post-training administration of WIN55, 212-2 (1μg/mouse), pre-test co-administration of noneffective doses of WIN55, 212-2 (0.25μg/mouse) and L-arginine (0.3 and1μg/mouse), increased the restoration of memory by the pre-test WIN55, 212-2. These findings may demonstrate the involvement of NO in state-dependent memory induced by intra-CA1 administration of WIN55, 212-2.

 
Keyword(s): WIN55, 212-2, STATE-DEPENDENT MEMORY, STEP-DOWN PASSIVE AVOIDANCE TASK, L-ARGININE, L-NAME, MICE
 
 
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