Paper Information

Title: 

THE EFFECT OF MATRICARIA RECUTITA AQUEOUS EXTRACT ON ACETIC ACID-INDUCED ULCERATIVE COLITIS IN RATS

Type: POSTER
Author(s): MASOUMI ARDAKANI Y.*,ABBASNEZHAD MAHDI,DERAKHSHANFAR AMIN,MOSTAFAVI A.,SHAMSPOUR T.,ESMAEILPOUR KHADIJEH
 
 *DEPARTMENT OF BIOLOGY, SCHOOL OF SCIENCES, SHAHID BAHONAR UNIVERSITY OF KERMAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Ulcerative colitis is a chronic inflammation of the large intestine (colon). In patients with ulcerative colitis, ulcers and inflammation of the inner lining of the colon lead to symptoms of abdominal pain, diarrhea, and rectal bleeding. Previous studies have shown that Matricaria recutita L. have a series of physiological effects as spasmolytic, carminative, antioxidant and anti-inflammatory. In the present study, the effect of this herbal extract on a model of acute experimental colitis was evaluated. Experiments were performed on 5 groups (N=7) of male NMRI rats (230-280 g). 3 groups were administered orally different doses of extract (10, 20 and 30 mg/kg), one group received vehicle and the last considered as control group. For induction of colitis the rats were fasted for 24 h and anaesthetized with ether, at the last stage 2 ml of acetic acid 4% was instilled via the anus. After 6 days the rats were sacrificed and some colon injuries or inflammatory indices were assessed by macroscopically and histopathologically methods. The extract (20 and 30 mg/kg) significantly reduced colon weight/length ratio. The extract at all doses (10, 20 and 30 mg/kg) significantly reduced severity and area of the ulcer, compared to control group. The histopathological studies of colon section showed that, curing or treating effects of extract 10, 20, and 30mg/kg is mild, moderate and completely, respectively. It is concluded that Matricaria recutita L. aqueous extract was effective in treatment against experimental acute colitis; it can decrease inflammatory indices of ulcerative colitis.

 
Keyword(s): ULCERATIVE COLITIS, MATRICARIA RECUTITA, ACETIC ACID, RAT
 
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