Paper Information

Title: 

CESAREAN SECTION AS A RISK FACTOR FOR DEVELOPING ASTHMA

Type: PAPER
Author(s): MANSOURI MAHBOUBEH*,ZANDIEH F.,MOVAHEDI MASOUD,GHARAHGOUZLOU MOHAMMAD,MOZAFARI H.,FARHOUDI A.A.H.
 
 *DEPARTMENT OF IMMUNOLOGY AND ALLERGY, CHILDREN MEDICAL CENTER, MEDICAL SCIENCES/UNIVERSITY OF TEHRAN
 
Name of Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Type of Seminar:  CONGRESS
Sponsor:  IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES
Date:  2007Volume 6
 
 
Abstract: 

Background: Cesarean delivery modifies infant gut bacterial flora composition which may result in hindered tolerance to allergens, thereby increasing the risk of asthma in accordance with hygiene hypothesis.
Objective: To determine the frequency of the cesarean delivery among the asthmatic patients.
Method & Material: A cross sectional study was designed and performed between Nov 2003 and Dec 2005 in immunology and allergy department. All the patients who were diagnosed as persistent asthma were enrolled in the study. A questionnaire containing the demographic data; (age, sex) sign and symptom, history of atopy and the route of birth (cesarean section versus normal vaginal delivery) were filled out for each patient.
Result: among 270 asthmatic patients who are studied, there was 163 male (60.4%), 107 female (%39.6).The mean ±SD age was 83.33±42.19 months .The mean ±SD age for the boys was 78.2±40.76 and the mean ±SD age for the girls was 91.15±43.33 months. 150 of them (55.6%) were products of a cesarean delivery and the birth in 120 of them (44.4%) was normal vaginal delivery. The rate of birth by cesarean route among the girls with asthma was 66.6% compared with 50.3% in male asthmatics.
Discussion: several characteristics of pregnancy including cesarean section have already been reported to influence the like hood of developing childhood asthma. Results of previous studies regarding an association between birth route and asthma are conflicting. The prevalence of the cesarean section in this asthmatic population was about 55.6%. In comparison with total population in which the rate of cesarean section is also elevated (>40% according to an unpublished data) this difference was meaningful (p<0.001).We found an association between cesarean as a rout of birth and asthma development. The small sample size and the confounding factors limit the interpretation and larger studies are required to confirm these findings.

 
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