Paper Information

Title: 

THE EFFECT OF STACHYS LAVANDULIFOLIA VAHL. EXTRACT ON GASTRIC ACID AND PEPSIN SECRETION AND GASTRIC ULCER IN RAT

Type: POSTER
Author(s): ADELI S.*,NABAVIZADEH F.,GOLESTAN M.,MOLOUDIAN HAMID
 
 *TEHRAN UNIVERSITY OF MEDICAL SCIENCE, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Stachys lavandulifolia Vahl. has shown antibacterial, antioxidant, antianorectic and antiinflamatory and analgesic effects. But little is known about the effects of Stachys lavandulifolia Vahl. on gastric ulcer and gastric secretions. This study was aimed to investigate the effects ofStachys lavandulifolia Vahl. extract on gastric secretions and gastriculcer. In this study, Wistar rats (n=32) were divided in to four groups, control, alcohol (1 ml/200 g) to induce ulcer, alcohol+extract (100 mg/Kg.gavaj) for 14 days and 14 days extract+alcohol. Under general anesthesia with 50 mg/Kg intra peritoneal (i.p.) sodium thiopental, after tracheotomy laparotomy was done and a cannula inserted in the stomach via duodenum. Gastric content was collected by “wash out” technique.Basal and stimulated acid and pepsin secretions were measured usingtitration and Anson method, respectively. In this study, pentagastrin (25μg/Kg,ip) was used as a stimulator. Histological studies will do in future. Results showed that the basal and stimulated acid and pepsin secretions in the alcohol and extract+alcohol groups were significantly less than control group (p<0.05). But there were no significant differences between alcohol+extract and control groups. It can be concluded that in alcohol+extract group, the extract can neutralize the effect of alcohol on gastric acid and pepsin secretions (return to the basal level).Therefore Stachys lavandulifolia Vahl. may be useful in gastric ulcer treatment. This hypothesis can be verified with histological studies.

 
Keyword(s): STACHYS LAVANDULIFOLIA VAHL. EXTRACT, GASTRIC ACID AND PEPSIN SECRETION, GASTRIC ULCER
 
Yearly Visit 11   tarjomyar
 
Latest on Blog
Enter SID Blog