Paper Information

Title: 

EXCITATORY EFFECT OF TERMINALIA CHEBULA RETZ IN GASTROINTESTINAL MOVEMENTS IN RATS

Type: POSTER
Author(s): MARD S.A.,VEYSI ALI,GHARIB NASERI MOHAMMAD KAZEM,MIKAEILI P.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

The present study was carried out to provide the pharmacological basis for the medical use of terminalia chebula in hypokinetic gastrointestinal disorders. In this study,ileum smooth muscle segments from male Wistar rats were suspended in organ bath containing tyrode’s solution and then the contractile frequency and isotonic tension were measured. The response to extract (0.01, 0.02 and 0.04mg/ml) and carbachol (10μM/L) and the effect of hexamethonium (10-4 mol/L), indomethacin (1μM/L), atropine (1μM/L) and verapamil hydrocholoride (1μM/L) on extract-induced contraction were also assessed (p<0.01). Results showed that the aquous extract of terminalia chebula dosedependently increased contractile frequency and it also increased contractile tension in the ileal smooth muscle segments in rats. These actions were not affected by pretreatment with hexamethonium, indomethacin, atropine but calcium channel blocker verapamil and free calcium tyrode’s solution inhibited both responses induced by extract. In conclusion, our results suggested that the aquous extract of terminalia chebula could increase contractile frequency and tension of ileal smooth muscle via calcium channel.

 
Keyword(s): ILEAL SMOOTH MUSCLE, TERMINALIA CHEBULA RETZ, CONTRACTILE FREQUENCY, RAT
 
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