Paper Information

Title: 

THE EFFECT OF PIOGLITAZONE, A SPECIFIC LIGAND OF THE PROXISOME PROLIFRATOR-ACTIVATED RECEPTOR GAMMA, ON ETHANOL-INDUCED GASTRIC ULCERS IN CHOLESTATIC RATS

Type: POSTER
Author(s): MOEZI LEYLA*,AMIR GHOFRAN Z.,NEKOUEIAN A.A.,JANAHMADI Z.,DEHPOUR A.R.
 
 *DEPARTMENT OF PHARMACOLOGY, SCHOOL OF MEDICINE, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

The frequency of gastrointestinal ulceration is higher in jaundiced patients than the normal population, but the exact mechanism of this increased frequency still remains uncertain. Recently it has been shown that pioglitazone, a specific ligand for peroxisome proliferator-activated receptor gamma (PPAR-g) exhibits gastroprotective and hyperaemic actions and accelerates the healing of pre-existing gastric ulcers. The present study was designed to investigate the effect of pioglitazone, on the mucosal lesions induced by ethanol in cholestatic rats. Cholestasis was induced by surgical ligation of bile duct and sham-operated rats served as controls. Both cholestatic and sham rats were kept for 7 days after the operation. Different groups of sham and cholestaotic animals received saline, or 5, 15 or 30 mg/kg pioglitazone, for 7 days. On day 8, rats were killed 1 hour after oral ethanol administration and the area of gastric lesions was measured. The ethanol-induced gastric mucosal damage was significantly more severe in cholestatic rats than sham-operated ones. Pretreatment with pioglitazone dose dependently attenuated gastric lesions induced by ethanol in both sham and cholestatic rats, but this effect was more significant in cholestatic ones. L NAME, a non selective inhibitor of nitric oxide synthase (NOS), decreased pioglitazone-induced gastric healing effect in cholestatic rats, while aminoguanidine, a selective inducible NOS inhibitor, increased pioglitazoneinduced gastric healing effect in cholestatic animals.
We conclude that chronic treatment with pioglitazone exerts a potent gastro protective effect on the stomach ulcers of cholestatic rats probably due to constitutive NOS induction.

 
Keyword(s): PIOGLITAZONE, GASTRIC ULCER, CHOLESTATIC RAT
 
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