Paper Information

Title: 

EFFECT OF ESOPHAGEAL DISTENTION ON GASTRIC BLOOD FLOW, GASTRIN AND SOMATOSTATIN SECRETION IN RAT

Type: POSTER
Author(s): MARD S.A.,GHARIB NASERI MOHAMMAD KAZEM*,BADVI M.
 
 *DEPARTMENT OF PHYSIOLOGY AND PHYSIOLOGY RESEARCH CENTER, SCHOOL OF MEDICINE, AHWAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHWAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

There are many studies about the inhibitory effect of the esophageal distention (ED) on gastric motility. However, there is not any investigation about the effect of the ED on the gastric blood flow and release of gastric hormones. The aim of this study was to investigate the effect of esophageal distention (ED) on gastric blood flow and release of gastrin and somatostatin hormones. In this study 79 male Wistar rats(175-230 g) were used. Before the experiments, animals deprived of food but not water 24 h. Under urethane anesthesia (1.2 g/kg, i.p.), animals underwent tracheostomy and laparotomy. A catheter was inserted in the stomach through duodenum for gastric distension. The esophagus was cannulated with a balloon orally to distend distal portion of esophagus (0.3 ml, 10 min). Saline was used for gastric distension (1.5 ml/100 g, b.w., pH 7 and 37°C). Gastric blood flow was measured by a Laser Doppler flowmeter. Gastrin serum and somatostatin plasma levels were assessed by RIA method. Vagotomy was carried out in a group to reveal the role of vagus nerve in this action. Results showed that ED reduced the blood flow of gastric proximal portion (P<0.001) but the antrum blood flow was unaffected by ED. Cervical vagotomy abolished the inhibitory effect of the ED on the proximal area blood flow. Gastrin serum level and somatostatin plasma level were unaffected by ED. in conclusion: Removal of the inhibitory effect of ED after vagotomy shows that the vagus nerve was involved in the inhibitory effect on gastric blood flow.

 
Keyword(s): ESOPHAGEAL DISTENSION, GASTRIC BLOOD FLOW, VAGUS NERVE, RAT, GASTRIN, SOMATOSTATIN
 
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