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Paper Information

Title: 

THE ASSESSMENT OF FREQUENCY OF HLA-B*27 SUBTYPES IN HLA-B*27 POSITIVE IN IRANIAN PATIENTS WITH ANKYLOSING SPONDYLITIS

Type: PAPER
Author(s): NIKNAM M.H.,AMIRZARGAR ALI AKBAR,MAHMOUDI MAHDI*,GANJ ALI KHANI HAKEMI M.,KHOSRAVI FARIDEH,JAMSHIDI AHMAD REZA,ANSARIPOUR B.,DORKHOUSH SH.,MORADI BATOUL,AMIRKHANI A.,NIKBIN BEHROUZ
 
 *IMMUNOLOGY DEPARTMENT, FACULTY OF MEDICINE, TEHRAN UNIVERSITY OF MEDICAL SCIENCE
 
Name of Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Type of Seminar:  CONGRESS
Sponsor:  IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES
Date:  2007Volume 6
 
 
Abstract: 

Introduction: HLA system or major histocomatibility system is one of the impotent factors in appearing many inflammatory diseases.
Ankylosing Spondylitis is an inflammatory spinal column diseases which according to survey in Iran 62.8% of this patients are HLA-B*27 positive. HLA-B*27 has different subtypes and for this reason these subtypes are very different in various races and important connection with diseases (side effects of Ankylosing Spondylitis). the detection of its subtypes in society is sectional that for first time is about to perform in Iran.
Objective: The detection of HLA-B*27 subtypes abundance in HLA-B*27 positive in Iranian patients with Ankylosing Spondylitis.
Method: We collect blood samples of 152 patients with Ankylosing Spondylitis and after screening for determining the HLA-B*27 positive samples with SSP-PCR method, and we separate 87HLA-B*27 positive patients and then we determine the HLA-B*27 subtypes.
Conclusion: Iranian AS patients have only 2 subtypes (HLA-B*2705, HLA-B*2702) of HLA-B*27 among 32 different subtypes.
Discussion: With determining and recognition of HLA-B*27 subtypes physicians can predict the side effects of this disease such as uveitis, IBD and …

 
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