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Paper Information

Title: 

STUDYING THE CENTRAL EFFECTS OF OXYNTOMODULIN ON FOOD INTAKE AND EXPRESSION OF RECEPTOR IN BROILER BRAIN STEM BY RT_PCR

Type: POSTER
Author(s): GHAZANFARI MOGHADAM A.*,JONEYDI H.,ABBASNEZHAD M.,YAGHOUBI M.M.,SEPEHRI HOURI,TORKZADEH M.
 
 *DEPARTMENT OF PHYSIOLOGY, SCHOOL OF BIOLOGY, UNIVERSITY COLLAGE OF SCIENCES, UNIVERSITY OF TEHRAN, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Oxyntomodulin (OXM), a proglucagon derived peptide, is a well known anorexigenic peptide found in the gut and brain of mammals. The present study was carried out to investigate whether central OXM induces satiety in broiler cockerels. Intracerebroventricular injection of various doses of OXM (1, 1.5, 2, 3, 4 and 6nmol), significantly decreased food intake 3 hours post injection in two different physiological conditions; fasting and non fasting. We conclude that OXM can act on the brain of birds to exert a suppression of feed intake. The aim of the present study was to investigate the effect of central oxyntomodulin (OXM) injection on expression of GLP-1R mRNA in the brainstem of chicks. RT-PCR results revealed that the expression of GLP-1R mRNA was decreased 30 and 90 min after injection of OXM. The present finding shows a negative regulatory effect of OXM on GLP-1R mRNA expression in the brainstem of chicks.

 
Keyword(s): OXYNTOMODULIN, FOOD INTAKE, INTRACEREBROVENTRICULAR INJECTION, GLP-1R MRNA, BRAINSTEM, CHICK
 
 
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