Paper Information

Title: 

EFFECT OF LISINOPRIL ON PARAQUAT-INDUCED LUNG FIBROSIS IN RAT

Type: SPEECH
Author(s): MOHAMMADI KARAKANI A.,GHAZI KHANSARI M.,SOTOUDEH M.,ASGHARZADEH HAGHIGHI S.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF TOXICOLOGY
Type of Seminar:  CONGRESS
Sponsor:  SOCIETY OF TOXICOLOGY
Date:  2004Volume 8
 
 
Abstract: 

Paraquat, a controversial herbicide, is one of the most used pesticides globally, in most countries. Although liver, kidney, heart and CNS are affected, selectively lung damage resulting pulmonary fibrosis is the usual cause of deaths. The mechanism of paraquat toxicity is not clear but the mechanism probably includes the induction of lipidperoxidation of unsaturation fatty acid. Lisinopril, an angiotensin converting enzyme inhibitor (ACEi), is an antihypertensive drug which has some beneficial effect in therapy of fibrosis. Antifibrotic effect of lisinopril has shown to be due to inhibition of synthesis of Angiotensin II which cause stimulation of fibroblast proliferation and collagen synthesis. In this study, Male albino Wistar rat weighing 150-300g was used in this experiment. Animals were divided into in five groups: The first group was given saline, the second group was given lisinopril (1 mg/kg), the third group was given paraquat (i.p. 20 mg/kg), the fourth was given lisinopril after i.p. of injection paraquat (treatment), and the fifth was given lisinopril before i.p. injection of paraquat (pre-treatment). After 7, 14, 21 days of treatment, the biochemical parameters such as hydroxyproline, glutathione and lipid peroxidation were determined in rat lung tissue. The results of this study demonstrated that paraquat caused a significant increase in hydroxyproline content, decrease in glutathione and glutathione/protein ratio (p<0.001) in rat lung tissue. Lisinopril significantly decreased the amount hydroxyproline (p<0.001) in rat lung tissue. The results also indicated that lisinopril can effectively protect the paraquat induced lung fibrosis. This antifibrotic effect of lisinopril may be due to inhibition of angiotensin II and TGF-b through its proline moiety

 
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