Paper Information

Title: 

EFFECTS OF DIFFERENT PERIODS OF RENAL ISCHEMIA/REPERFUSION INJURY ON RAT LIVER FUNCTION, CYTOKINE LEVELS AND ANTIOXIDANT STATUS

Type: POSTER
Author(s): KADKHODAEI MEHRI*,GOLAB F.,ZAHMATKESH MARYAM,GHAZNAVI R.,HEDAYATI MAHDI,ARAB H.A.,SOLEYMANI MANOUCHEHR
 
 *DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICINE, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

The effect of ischemia/reperfusion (I/R) injury to the kidney has been under investigation for many years. But the changes in liver function and oxidative stress status in renal I/R injury is not well known. Recent studies suggest a crosstalk between the liver and the kidneys. The aim of the present study was to assess the liver changes after induction of various degrees of renal I/R injury.
Twenty male rats were subjected to either sham operation or ischemia (30, 45 and 60 min) followed by 60 min reperfusion. Blood samples were drawn postoperatively and serum creatinine, BUN, ALT, AST were measured. Hepatic glutathione (GSH) and FRAP (ferric reducing antioxidant power) levels and the concentration of IL-10, tumor necrosis factor (TNF) -alpha were evaluated.
Induction of 45 min renal ischemia-60 min reperfusion caused a significant reduction in renal function demonstrated by increase in plasma BUN and creatinine concentrations. These rats showed a significant decrease in liver GSH as well as significant increase in TNF-a & IL-10 concentrations.
Renal ischemia causes changes in liver function and oxidative stress status. A minimum of 45 min ischemia is needed to study the effects of renal injury on liver as a remote affected organ.

 
Keyword(s): KIDNEY, ISCHEMIA-REPERFUSION, LIVER, CYTOKINES
 
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