Paper Information

Title: 

EVALUATION HISTOPATHOLOGICAL AND FUNCTIONAL CHANGES OF RAT KIDNEY FOLLOWING ATORVASTATIN AND ERYTHROMYCIN ADMINISTRATION

Type: POSTER
Author(s): POURMOUSAVI SEYEDEH MAHSA*,NAJAFZADEH HOSSEIN,MOROVATI HASAN,MOHAMMADIAN BABAK,RAAZI JALALI M.
 
 *SHAHID CHAMRAN UNIVERSITY AHVAZ
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

The statines (including Simvastatin, Levovastatin and Atorvastatin) or HMG Co-A reductase inhibitors may be the most causative factor of rabdyimylosis which can produce renal failure. The cytochrom p-450 is an important enzyme involved in the induction of this failure. The inhibition of this enzyme can reduce renal toxicity. The aim of the present study was evaluating the effects of Atorvastatin and Erythromycin on functional andhistopathological changes in kidney of rats. The study was done in 4 groups of rats. Normal saline, Atorvastatin, Erythromycin and combination of them were administrated in group 1 to 4 respectively for 15 days. The serum functional renal factors including BUN, creatinine, sodium and potassium were measured. The kidney was removed and processed for histopathological examination which was conducted by H&E staining and light microscope. The results showed that Atorvastatin or Erythromycin or their combination did not significantly change serum levels of factors related to kidney function. The histopathological examination showed that these drugs may injure the kidney, and their co-administration may increase the level of injury threefold. The histopathological changes were included acute tubular necrosis, cell swelling, intermediate nephritis and hyperemia. Therefore, concomitant consumption of Erythromycin and Atorvastatin can increase kidney toxicity.

 
Keyword(s): ATORVASTATIN, ERYTHROMYCIN, HISTOPATHOLOGICAL CHANGES, KIDNEY, RAT
 
Yearly Visit 17   tarjomyar
 
Latest on Blog
Enter SID Blog