Paper Information

Title: 

THE SURVEY OF POSITIVE AND NEGATIVE CASES OF SERUMIC ANTISPERM ANTIBODIES IN FERTILE AND INFERTILE PEOPLE

Type: PAPER
Author(s): KARIMI F.*,KHAZAEI S.,MORADI B.,ALA ALDIN F.,KARIMI V.,RAFINEZHAD A
 
 *DEPARTMENT OF IMMUNOLOGY, FACULTY OF MEDICINE, SHAHEED BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, IRAN
 
Name of Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Type of Seminar:  CONGRESS
Sponsor:  IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES
Date:  2007Volume 6
 
 
Abstract: 

Background: Presence of antisperm antibodies (ASAs) in infertility and their negative effects on fertility is subject of challenges among researchers. Most of studies show different and controversy results.
Methods: Investigating of condition of serumic ASAs (IgG, IgM and IgA) in fertile and infertile people, we applied flow cytometry technique using serum of 29 fertile and 61 infertile men and women.
Results: Comparing the mean of different classes of ASAs (IgG, IgM and IgA) in fertile and infertile people showed no meaningful difference. Comparing the serumic ASAs (IgG, IgM and IgA) positive fertile and infertile cases showed no significant and meaningful difference.
Conclusion: The results of this survey show that the study of presence of ASAs using the method applied in this study (and similar studies), is not useful in prognostication of the role and effect of ASAs in infertile people. However, regarding with negative effect of many types of ASAs in reduction of rate of fertility, instead of assaying of total ASAs, we recommend the assay of those ASAs witch exert special effects on sperm (including antibodies which damage fertilization, activate the complement cascade, etc.).

 
Keyword(s): ANTI SPERM ANTIBODIES, FLOW CYTOMETRY, ASSAY, FERTILITY, INFERTILITY
 
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