Paper Information

Title: 

EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF MORPHINE AND WIN55212-2 ON URINE OUTPUT AND WATER CONSUMPTION OF MALE RATS

Type: POSTER
Author(s): MANSOURI Z.,NADERI NIMA,MOTAMEDI F.,SHAFAGHI B.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Opioid and cannabinoid receptors have been found both in the hypothalamic regions of brain and in kidneys. Hence, their receptor agonists possibly have pharmacological activity on urine output. In this study, we investigated the effect of intracerebroventricular (i.c.v.) administration of opioid receptor agonist morphine and cannabinoid receptor agonist WIN55212-2 on urine output and water consumption of male rats using metabolic cages. One week after surgery, the animals were transferred into metabolic cages and were kept their individually for4 days. Daily measurement of urine output and water consumption was performed during the test. The first day was considered as control and each group received i.c.v. injection of one dose of either morphine or WIN55212-2 for three consecutive days. Our results showed that i.c.v. administration of morphine at the dose of 200 μg increased urine output in compared to control group. In contrast, i.c.v. administration of WIN55212-2 (10 and 50 μg) significantly decreased urine output compared to control group. However, significant changes in daily water consumption were not observed in any of groups received various doses of either morphine or WIN55212-2 compared to control group. We suggest that pharmacological doses of cannabinoid and opioid agonists can affect urine output through brain regions involved in water homeostasis (such as hypothalamus) and cannabinoid and opioid compounds produced opposite effects in this regard.

 
Keyword(s): CANNABINOID, OPIOID, URINE OUTPUT
 
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