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Paper Information

Title: 

STUDY OF CORRELATION BETWEEN ACE ACTIVITY AND CORONARY ARTERY DISEASE

Type: POSTER
Author(s): SAKEN SHAFT MINA*,ANSARIAN A.,ZIAEI S.A.,NASRI SIMA,SAADAT H.A.
 
 *DEPT. BIOLOGY, PAYAME NOOR UNIVERSITY, TEHRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Introduction: Angiotensin converting enzyme (ACE) is an exopeptidase that converts Angiotensin I to Angiotensin II. Angiotensin II is a potent vasoconstrictor and causes aldosterone release, so it is a critical role in hypertension. In this study the correlation between ACE activity in patients with coronary artery disease and in normal subjects as well as with other important risk factors was determined.
Methods: 115 subjects based on angiography results were divided into patients and normal persons. Serum ACE activity of these subjects was assayed by HPLC. Diabetes mellitus, hypertension, lipid profiles, ejection fraction, smoking and opium consumption were also recorded or determined. Data were processed by SPSS software.
Results: ACE activity was higher in hypertensives and diabetics in patients group (p<0.001), but it had not any correlation with these risk factors in normal subjects. Results didn’t show any correlation between ACE activities with coronary artery disease or other risk factors.
Conclusion: Hypertension is a major risk factor in coronary artery disease, and renin angiotensin system has a critical role in hypertension and atherosclerosis. We conclude that ACE activity is a good index in patients with heart disease.

 
Keyword(s): ANGIOTENSIN CONVERTING ENZYME, CORONARY ARTERY DISEASE, CAD
 
 
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