Paper Information

Title: 

COMPLICATIONS OF ASTHMA MEDICATIONS

Type: PAPER
Author(s): JAVAHER TARASH N.*
 
 *IMMUNOLOGY AND ALLERGY WARD, RASOOL AKRAM HOSPITAL, IRAN UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Type of Seminar:  CONGRESS
Sponsor:  IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES
Date:  2007Volume 6
 
 
Abstract: 

Studies have reported that overuse of beta-agonists is associated with increased death or near death episodes from asthma. This is a major concern for some patients with asthma who rely on short-acting beta-agonists as a "quick fix" for their asthma, so it is helpful to monitor the frequency of inhaled beta-agonist use.
Adverse effects of frequently administered beta-agonist therapy include: tremor, irritability, arrhythmia, tachycardia, and hypokalemia, and CNS irritability. Patients requiring frequent or continuous nebulized beta-agonist therapy should have continuous cardiac monitoring, because frequent use can cause ventilation-perfusion mismatch and precipitate hypoxemia (oximetry is indicated).
Adrenergic agents should be administered with caution in elderly patients and those with cardiac disease.
IPROTROPIUM BROMIDE, is available in both MDI and nebulizable formulations, it is widely used in children with asthma and it is approved by u.s. food and drug administration (FDA) in children >12 years of age.
Side effects: dry mouth, dizziness, blurred vision, urinary retention, nervousness.
CORTICOSTEROIDS: oral or inhaled in high dose may develop suppression of the hypothalamic-pituitary adrenal axis with adrenal insufficiency. Side effects: hoarsness candidiasis in oropharynx or larynx, cataracts, psychiatric disturbances, osteoporosis, delayed growth. Systemic corticosteroid effects as hypercorticism and adrenal suppression, cushings syndrome, muscular atrophy, hypertension, glucoma, aseptic bone necrosis, pancreatitis, GI-bleeding, cerebral pseudotumor, CHF, convulsions.
SALBUTAMOL OR ALBUTEROL: side effects: tremor, heart palpitation, muscle cramps, psychotic reaction.
SALMETEROL (serevent): side effects: HBP, arrhythmia, liver dysfunction and damage, chest pain, worsening of bronchospasm, anaphylaxis, hypokalemia, heart complications.
THEOPHYLINE: Side effects: nausea, vomiting, abdominal pain, tachycardia, palpitations, tremor, GER, arrhythmias, convulsion MONTELUKAST (singulair): side effects: headache, abd-pain, rash, dizziness, diarrhea, cough.
COROMOLYN SODIOM: side effects: hoarseness, coughing, burning and stinging.
CONCLUSIONS: the drugs that we choose for asthmatic patients should be appropriate with less price and without complications.

 
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