Paper Information

Title: 

THE EFFECTS OF ALCOHOLIC EXTRACT OF URTICA DIOICA ON LIPID PROFILE IN HYPERCHOLESTEROLEMIA DIET IN RATS

Type: POSTER
Author(s): ABBASI ESMAEIL*,NASIRIASL M.,DANESHI M.M.,SHAHSAVAN MASOUMEH
 
 *DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICINE, QAZVIN UNIVERSITY OF MEDICAL SCIENCES, QAZVIN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Urtica dioica is a perennial herb in Iran and there are several reports on its pharmacological effects. Regarding the antioxidant and hepatoprotective properties of this herb, the aim of this study was to investigate its effect on lipid profile in rats. We used a hypercholestrolemic diet which was gavaged to animals for 28 days. Then the effect of Urtica extract in the presence of this diet on lipid profile was evaluated. The rats were divided into five groups, each comprised of ten animals. First group received peanut oil orally. Second group only received cocktail (hypercholestrolemic diet). Third group received cocktail+lovastatin 10 mg/kg. Two last groups received cocktail+Urtica extract at the doses of 100 or 300 mg/kg respectively. Results showed that Urtica extract (100 and 300 mg/kg) could significantly reduce total cholesterol of plasma compared to cocktail group. Also, Urtica extract (100 and 300 mg/kg) could decrease plasma AST and ALT. In conclusion, in this study the most effective response to Urtica extract was appeared at 100 mg/kg. Moreover, this extract could protect liver against elevation of the enzymes. About mechanism, it is possible that the sterol compound of the extract can contribute to absorbance and storage of cholesterol. Furthermore, antioxidant activity and free radical scavenging of extract may enhance hypercholestrolemic effects.

 
Keyword(s): URTICA DIOICA, HYPERCHOSTRLEMIA, AST, ALT
 
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