Paper Information

Title: 

THE EFFECTS OF DIAZEPAM IN CARDIODEPRESSANT CONCENTRATION ON THE FUNCTION OF ISOLATED RAT HEART IN ISCHEMIA-REPERFISION

Type: POSTER
Author(s): SHAKIBAEI D.,GOUDINI A.A.,RESHADAT S.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Regarding the common clinical usage of benzodiazepines in medicine; the aim of this study is to investigate the effects of cardiodeppressant concentration of diazepam on the function of isolated rat heart in ischemia- reperfusion. Isolated, perfused rat hearts were subjected to 40 min normothermic global ischemia and 45 min reperfusion. Diazepam [100 Micromole per liter (μM)] was added to the perfusion solution for 10 min before ischemia in the test group. Different cardiac variables including left ventricular developed pressure (LVDP), heart rate (HR) and coronary flow (CF) were measured. Rate pressure product (RPP) was calculated, and maximum contracture was determined during the ischemic period. In reperfusion, cardiac functional recovery was determined. It was found that diazepam significantly decreased RPP and increased CF before ischemia. In diazepam group (n=10), during ischemia, maximum contracture was significantly lower than the control group (n=14). Also diazepam significantly increased functional recovery and coronary flow in reperfusion. In conclusion, Diazepam (100μM) significantly decreased maximum contracture during ischemia and improved the recovery of myocardial function and coronary flow in reperfusion. The results show that the cardio depressant concentration of diazepam is safe and relatively protective in the ischemia- reperfused isolated rat heart. These effects may be mediated by the inhibition of calcium current in cardiomyocytes.

 
Keyword(s): ISOLATED RAT HEART, DIAZEPAM, MYOCARDIAL ISCHEMIA, REPERFUSION
 
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