Paper Information

Title: 

ASSOCIATION BETWEEN SERUM NITRIC OXIDE METABOLITES AND HYPERTENSION IN A GENERAL POPULATION

Type: POSTER
Author(s): GHASEMI ASGHAR*,ZAHEDIASL S.,AZIZI FEREYDOUN
 
 *ENDOCRINE RESEARCH CENTER, RESEARCH INSTITUTE FOR ENDOCRINE SCIENCES, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Hypertension affects approximately one billion individuals worldwide, and relation between hypertension and risk of cardiovascular disease is well known. Nitric oxide (NO) plays a fundamental role in regulating vessel wall homeostasis. Endothelial dysfunction and impaired release of endothelial NO occurs in hypertension. The aim of this study was to determine relation between NO metabolites (NOx) concentrations and blood pressure (BP) levels in a general population. In a cross-sectional study, NOx was measured in 2968 adult subjects, selected from a population-based study, using the Griess method. Classification of blood BP category was done according to the seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high BP. Results showed that Serum NOx values were negatively correlated with systolic BP 160 mmHg in men (r=-0.523, p=0.002). In women, both systolic BP (r= 0.085, p=0.001) and diastolic BP (r=0.106, p<0.001) were positively correlated with serum NOx levels in normotensive subjects. Serum NOx was higher in men with stage 1 hypertension while those with stage 2 hypertension had significantly lower NOx. In men, medication increased serum NOx concentration in both stages of hypertension but in women, a significant increase was observed only in stage 1 hypertension. In conclusions, serum NOx decreased in untreated stage 2 hypertension and increased in stage 1 hypertension in men. These findings suggest that measurement of NOx in male hypertensive subjects might be helpful for assessing endothelial (dys) function.

 
Keyword(s): NITRIC OXIDE, HYPERTENSION, ENDOTHELIUM
 
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