Paper Information

Title:  DECREASE OF VETRICULAR FIBRILLATION INCIDENCE BY NATURAL HONEY DURING GLOBAL ISCHEMIA
Type: POSTER
Author(s): ZAHEDNEZHAD F.*,NAJAFI MOSLEM,VAEZ H.,SAMADZADEH MEHRABAN
 
 *STUDENT RESEARCH COMMITTEE (SRC), TABRIZ UNIVERSITY OF MEDICAL SCIENCE, TABRIZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Honey is one of the best energy sources. It has been used to treat a variety of ailments including cardiac pain and heart palpitation. However, its cardioprotective effects have not scientifically proven. In this study, the effects of natural honey on incidence of irreversible ventricular fibrillation (Irr. VF) during global ischemia was investigated in isolated rat heart. Isolated rat hearts were divided into four groups (1 control and 3 test groups; n=10-15 in each group) then mounted on a Langendorff apparatus at constant temperature and pressure. In the control group, the hearts were perfused by normal Krebs-Henseleit (K/H) solution during stabilization and 30 min global ischemia followed by 30 min reperfusion, however in the test groups they were perfused with 0.25%, 0.5% and 1% of honey-enriched K/H solution for 15 min before induction of global ischemia. The ECGs were recorded and analyzed to determine Irr. VF incidence based on the Lambeth conventions. Analysis of the ECGs showed that perfusion of different honey concentrations in the test groups produce significant reduction in the incidence of Irr. VF compared to the control group (p<0.05 for all). The results showed that honey with the above concentrations has cardioprotective properties as significant decrease in the incidence of Irr. VF. Although the mechanism of action is unknown, it is probably that the antioxidant content of natural honey may have contributed to these protective effects.

 
Keyword(s): NATURAL HONEY, VENTRICULAR FIBRILLATION, GLOBAL ISCHEMIA, ISOLATED HEART
 
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