Paper Information

Title: 

PRECONDITIONING WITH MORPHINE DEPENDENCY IMPROVES CORONARY FLOW AND MECHANICAL ACTIVITY IN ISOLATED RAT HEART

Type: POSTER
Author(s): MAZLOUM R.*,HAJIZADEH S.,SEMNANIAN S.,POURKHALILI KH.
 
 *CARDIOVASCULAR LAB., NO.3 MEDICAL BUILDING, TARBIAT MODARES UNIVERSITY, TEHRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Introduction: morphine dependency has major effects on various tissues. One of the most one is preconditioning, that protect heart against ischemia/reperfusion injury occurring in heart stroke, cardiopulmonary bypass surgeries and heart transplantation. The present study investigated whether morphine dependency elicits a precondition like response on coronary flows and mechanical activity in heart.
Materials and methods: male wistar rats were used in this study. Morphine dependency was induced by injection of 10mg/kg morphine sulfate, twice a day for 10 days. Hearts were isolated with langendorf system and perfuse after last injection. local ischemia was induced for 30 minutes by occluding the left anterior descending coronary artery and then exposed to reperfusion for 120 minutes. Coronary flow was measured by collection of the coronary effluent. Left ventricular pressure was measured by using powerlab system.
Results: results indicate that morphine dependency can reduced the effects of ischemia/reperfusion injuries on mechanical activity) improved left ventricular developed pressure, maximum of dp/dt, and rate pressure product) and coronary flow during reperfusion significantly (p<0.001).
Discussion and conclusion: in conclusion, morphine dependency mimics preconditioning that improves coronary flow and mechanical activity of heart after ischemia.

 
Keyword(s): MORPHINE DEPENDENCY, PRECONDITIONING, CORONARY FLOW, LEFT VENTRICULAR DEVELOPED PRESSURE, MAXIMUM OF DP/DT, RATE PRESSURE PRODUCT, ISCHEMIA/REPERFUSION INJURY
 
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