Paper Information

Title: 

THE COMPARISON OF SALIVARY IGA AND IGE LEVELS IN CHILDREN WITH BREAST- AND FORMULA-FEEDING DURING INFANCY PERIOD

Type: PAPER
Author(s): JAFARZADEH A.,HASAN SHAHI GH.,KAZEMI ARABABADI M.,MOSTAFAEI A.,SADEGHI M.,NEMAT ELAHI M.A.,REZAYATI M.T.,NEMATI M.
 
 
 
Name of Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Type of Seminar:  CONGRESS
Sponsor:  IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES
Date:  2007Volume 6
 
 
Abstract: 

Introduction and Aims: Local oral immune factors may play a role in the protection against oral diseases and defences against microbial agents. Salivary immunoglobulin A (IgA) is a major factor for the local host defence against caries and periodontal disease. The aims of this study were to determine the concentrations of salivary IgA and IgE levels in breast-fed and formula-fed children at infancy period.
Material and Methods: Totally, 80 healthy 5-year children were included in the study. According to the type of feeding at infancy period, the children were divided into two groups. 50 breast-fed and 30 formula-fed in infancy period. One millilitre of saliva was collected from all participants and centrifuged and stored at -70˚C. The salivary IgA and IgE concentrations were measured using of ELISA technique.
Results: In breast-fed children the salivary IgA levels (39.6mg/l±17.3) were significantly (p=0.0001) higher than that observed in formula fed-children (26.9mg/l±14). However, the salivary IgE levels were significantly (p=0.047) lower in breast-fed compared with formula-fed children (5.01 IU/ml±19.70vs 11.7IU/ml±39.4).
Conclusion: The results indicate that breast feeding enhances salivary IgA levels in the early period of life which may contribute to oral cavity immunity. However, higher levels of salivary IgE levels were observed in formula-fed subjects, which may have a potential role for the development of allergy or inflammatory reactions.

 
Keyword(s): BREAST FEEDING, FORMULA FEEDING, SALIVA, IGA, IGE, CHILDREN
 
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