Paper Information

Title: 

EFFECT OF CO-ADMINISTRATION OF GARLIC AND CHLORPROPAMIDE ON BLOOD GLUCOSE IN DIABETIC RATS

Type: POSTER
Author(s): KARAMI BONARI A.R.*
 
 *DEPARTMENT OF PHARMACOLOGY, FACULTY OF VETERINARY, MEDICINE ISLAMIC AZAD UNIVERSITY, SHABESTAR BRANCH, SHABESTAR, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Diabetes mellitus is a common endocrine disorder characterized by hyperglycemia. Polytherapy is said to be a current pharmacological principle having the advantage of producing maximum therapeutic efficacy with minimum side effects. Garlic is one of the most popular herbs used worldwide to reduce various risk factors associated with diseases. We assessed the antidiabetic efficacy by a combination of garlic and chlorpropamide. Fifty Wistar rats, 10 non-diabetic and 40 induced-diabetic rats by alloxan (150mg/kg b.w, i.p), were used. The diabetic rats were divided equally into 4 groups: group 1: treated with saline (2ml/kg p.o, diabetic control), group 2: treated with chlorpropamide (250mg/kg p.o.), group 3: treated with garlic (0.5g/kg p.o.) and group 4: treated with chlorpropamide and garlic. All drugs were given for 24 days. Chlorpropamide and garlic and their combination produced significant (P<0.05) reductions in blood glucose concentrations of diabetic (hyperglycemic) rats. The maximum reduction occurred in group 4. In the group treated with combined chlorpropamide and garlic, effects were synergistic, hence more beneficial than individual treatments.

 
Keyword(s): DIABETES MELLITUS, GARLIC, CHLORPROPAMIDE, RAT
 
Yearly Visit 14   tarjomyar
 
Latest on Blog
Enter SID Blog