Paper Information

Title: 

PREVENTIVE EFFECT OF TREADMILL EXERCISE ON LIPID PEROXIDATION AND HISTOPATHOLOGICAL CHANGES IN ISOPROTERENOL-INDUCED CARDIOTOXICITY IN MALE RATS

Type: POSTER
Author(s): MIRZAEI FARIBA*,AFSHIN S.,MOHAMMADI MOSTAFA,BADALZADEH R.,RASHIDI BAHMAN,MOHADES GISOU
 
 *DRUG APPLIED RESEARCH CENTER, SCHOOL OF MEDICINE, TABRIZ UNIVERSITY OF MEDICAL SCIENCES, TABRIZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

The cardiotoxic effects of isoproterenol (ISO) are associated with, and possibly due to, lipid peroxidation in heart tissue. In this study, the effect of exercise against lipid peroxidation and injuries due to isoproterenol was investigated in rat heart. Fifty Wistar rats were divided into 5 groups: control rats (C), saline (S), Exercise (E), ISO injected (150 mg/kg) (ISO), Exercise + ISO (E+ISO). The treadmill exercise protocol was 30 minutes running at 20-25meters per minute in 5 days/week in the period of 8 weeks. At the end of the experiment, all animals anesthetized and heart tissues were collected for biochemical and histological examinations. Treadmill exercise increased GSH, GSSG and decreased TBARS levels in ISO group (p<0.05). Also, exercise reduced the rate of edema, inflammatory cells infiltration and degree of necrosis compared with control group. Our results show that exercise by reduction of lipid peroxidation and intensity of myocardial injuries may have beneficial protective effects against injuries due to isoproterenol.

 
Keyword(s): EXERCISE, LIPID PEROXIDATION, ISOPROTERENOL, RAT
 
Yearly Visit 27   tarjomyar
 
Latest on Blog
Enter SID Blog