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Paper Information

Title: 

EFFECT OF GRAPE SEED EXTRACT (GSE) ON AORTA RESPONSE TO VASODILATOR AGENTS IN LEAD EXPOSED RATS

Type: POSTER
Author(s): ZARE MEHRJERDI F.*,BADVI M.,SARKAKI A.R.,GHARIB NASERI MOHAMMAD KAZEM,DIANAT MAHIN
 
 *DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICINE, IRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Exposure to low level of lead results in decreased vasodilator response of aorta to vasoactive agents in rats. This metal has adverse effects on different human systems including cardiovascular system. Several studies indicated the involvement of Reactive Oxygen Species (ROS) in Lead-exposed animals. On the other hand Grape Seed is a good source of antioxidants and have free radical scavenging properties. The aim of this experiment was to determine the effect of Grape Seed Extract (GSE) on isolated aorta response to acetylcholine (ach) (endothelium-dependent vasorelaxant) and sodium nitroprusside (snp) (endothelium-independent vasorelaxant). Forty adult male Wistar rats were dividedinto four groups. Control group, received tap water (A). The other three groups received tap water contained 100ppm lead acetate alone (B), GSE alone (100mg/kg, orally, C) or 100ppm lead acetate in drinking water + GSE (100mg/kg, orally, D) for 45 days. The results of this study indicated that chronic exposure to lead could reduce aortic response to ach and snp. This reduction in aorta contractility response was prevented by GSE (P<0.001). It can be concluded that GSE possibly through its antioxidative properties could have beneficial and preventive effects on lead indicated vasoactive responses.

 
Keyword(s): GRAPE SEED EXTRACT, AORTA, VASODILATOR AGENTS, LEAD
 
 
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