Paper Information

Title: 

EFFECT OF EXERCISE ON LIPID PEROXIDATION AND OXIDATIVE STRESS IN ISOPROTERENOL-INDUCED CARDIO INJURY IN MALE RATS

Type: POSTER
Author(s): MOHAMMADI MOSTAFA*,AFSHIN S.,BADALZADEH R.,MOHADES GISOU,VATANKHAH A.M.
 
 *SCHOOL OF MEDICINE, DRUG APPLIED RESEARCH CENTER, TABRIZ UNIVERSITY OF MEDICAL SCIENCES, TABRIZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Myocardium infarction (MI) is the leading cause of mortality and morbidity in the developed and developing countries. Oxidative stress is a key factor of cellular injury in cardiovascular diseases. Isoproterenol (ISO) in high doses causes myocardium infarction. The cardiotoxic effects of isoproterenol (ISO) are associated possibly due to enhancement of lipid peroxidation and oxidative stress in heart tissue. In the present study, 50 Wistar rats were divided into 5 groups (n=10): control rats, saline, exercise, ISO injected (150 mg/kg), exercise + ISO. At the end of the experiment all animals anesthetized and the heart tissue samples were collected for biochemical examinations. Exercise increased GSH, GSSG but had no significant effect on SOD and catalase activities. Exercise also decreased TBARS level in ISO group (p<0.05). Our results show that exercise may reduce the lipid peroxidation and oxidative stress induced by ISO administration. In conclusion, it seems pretreatment with exercise as a non-drug tool can be beneficial for protection of sudden death induced by cardiovascular diseases.

 
Keyword(s): EXERCISE, LIPID PEROXIDATION, OXIDATIVE STRESS, ISOPROTERENOL, MALE RAT
 
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