Paper Information

Title:  EFFECTS OF MIDAZOLAM ON MORPHINE AND TRAMADOL ANALGESIA
Type: POSTER
Author(s): TAYEBI E.*,BABAZADEH N.,HASHEMI MARIA,MOGHADAMNIA ALI AKBAR
 
 *PHARMACOLOGY GROUP
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Midazolam is a sedative–calmative drug from benzodiazepines family which is used in order to make relaxation and amnesia in medical and surgical therapy such as endoscopy, bronchoscopy and anesthesia pre-drug. Midazolam pretreatment on morphine & tramadol analgesia was studied. The mice were divided into two groups, midazolam (2.5 mg/kg, i.p.) pre-treatment and saline-pretreatment. Each group was divided into 3 subgroups (saline, morphine 20mgr/kg and tramadol 12.5mgr/kg). The baseline tolerances of all groups were measured by hot-plate method (53-54oC, cut-off time: 40sec). One hour after the initial injection (midazolam and/or saline), pain tolerance of mice was measured in 6 steps by interval of 15 minutes. Results showed that midazolam pretreatment can improve morphine analgesia compared to saline (p<0.05). With the exception of the effect in 60 min, there was no significant difference of the effect of midazolam pretreatment on the tramadol analgesic effect at any time of analgesia assessment.
In conclusion, according to the results, midazolam pretreatment could increase morphine analgesia in comparison to tramadol at any time of the assessment.

 
Keyword(s): ANALGESIC, MIDAZOLAM, TRAMADOL, MORPHINE
 
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