Paper Information

Title:  EFFECT OF HEPARIN INFUSION ON FAT METABOLISM AND ENDURANCE PERFORMANCE
Type: POSTER
Author(s): IZADI MOJTABA*,EGHDAMI A.
 
 *ISLAMIC AZAD UNIVERSITY SAVEH BRANCH, SAVEH, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

 During endurance exercise, skeletal muscle relies mainly on both carbohydrates (CHO) and fat oxidation to cover energy needs. Fatty acids are an important source of energy for skeletal muscle contraction, particularly during exercise of mild-moderate intensity, prolonged duration. This clinical trail study examined the effect of heparin infusion (10000 U) on fat metabolism during steady-state exercise in human. Forty-boy students performed 20-minute exercise protocol on cycle ergometer on two separate occasions (stage1: without any infusion, stage 2: with heparin and lactose infusion in order of experimental and control group in 30-minute prior of test). Blood samples were drawn immediately followed up exercise for the purpose of calculation plasma free fatty acid (FFA), triglyceride (TG). A MANOVA test was used to determine significant differences between the two groups. Statically significant was accepted at p<0.05. The statically findings showed that heparin infusion led to significantly increase of FFA and significantly decrease in TG in experimental group (P<0.05). The rest heart rate decreased significantly (P<0.05). VO2max also were not changed. All variables were unaffected of lactose in the control trial. These findings indicate that heparin infusion lead to increase in fat oxidation that probably associated with decrease in glycogen consumption and fatigue delay during endurance exercise. Simultaneous measurement of fat-carbohydrate oxidation substrates is necessary for perfect determination effect of these supplementations on endurance performance during exercise.

 
Keyword(s): HEPARIN, FREE FATTY ACID, FAT METABOLISM, EXERCISE, ENDURANCE PERFORMANCE
 
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