Paper Information

Title: 

DETERMINATION OF DEXTROMETHORPHAN IN DRUG MARKET OF IRAN USING HPLC METHOD

Type: POSTER
Author(s): HEYDARI AMIR*,PEYRAVI T.
 
 *DEPARTMENT OF PHARMACOLOGY, FACULTY OF MEDICINE, URMIA MEDICAL SCIENCES UNIVERSITY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Background: Quality control most commonly functions to test and measure material and product. Quality control is responsible for the control of quality within a company and evaluating product stability. The packaged product will be stable for its anticipated shelf life throughout the various stages of the development process. Each active ingredient retains its chemical integrity and labeled potency within the specified limits. The purpose of this study was to determine the amount of dextromethorphan in drug market available in Iran.
Method: For this purpose the four pharmaceutical formulations of dextromethorphan with different serial code number preparations were purchased from the market. Based on their standard methods of extraction (USP Pharmacopeia), the active ingredient, dextromethorphan was extracted and injected to the HPLC Colum. The method utilize fluorescence detector.
Results: The results of these projects about 40 commercial products were as follow: The respective forms of pharmaceutical tablets, 104-124%, drops 3.48-3.66%, simple syrup, 13.59-17.73% and syrup mixture 109-120% of labeled.
Conclusion: The assay results obtained for forty commercially available formulations of tablet, syrup were greater than the amounts declared, which agree with the tolerances indicated by the USP pharmacopeia, while the assay results for drops were less than values declared.

 
Keyword(s): HPLC, USP, DEXTROMETHORPHAN
 
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