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Paper Information

Title: 

MODE OF DELIVERY IS ASSOCIATED WITH ASTHMA AND ALLERGY OCCURRENCES IN CHILDREN AND ADULTS

Type: PAPER
Author(s): GHAFARI J.*,MOHAMMADZADEH I.,NAZARI Z.,GHARAHGOZLOU M.,MAHDAVI M.
 
 *DEPARTMENT OF PEDIATRICS, MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, SARI, IRAN
 
Name of Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Type of Seminar:  CONGRESS
Sponsor:  IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES
Date:  2007Volume 6
 
 
Abstract: 

Introduction: A growing body of evidence indicates that perinatal factors modulate immune development and thereby may affect childhood asthma risk. In this study, we examined the associations between birth by Cesarean Section (C-section) and atopic disease (asthma) occurrence in children and adults.
Methods: Subjects were born in Iran and were over 5 years old during their enrollment in the Children's Medical Center. Our analysis was restricted to 228 children born at or after 37 weeks of gestation with a birth weight of 2500 g or greater based on birth certificate data. Information about sociodemographic factors, reporting physician-diagnosed asthma and other atopic diseases, was obtained by using a self-administered structured questionnaire. Logistic regression models were fitted to compute odds ratios (ORs) and 95% confidence intervals (CIs).
Results: The Cesarean section and normal Delivery were 65.78% (i.e., 150 of 228), 34.22 %(78 of 228) in the asthmatic group respectively but were 74.13% (129 of 174) and 25.85% (45 of 174) in the normal health subjects respectively. Children and adults born by C-section were at increased risk for asthma (OR, 1.33; 95% CI, 1.01-1.75) compared with those born vaginally.
Conclusion: We conclude that birth by C-section or processes associated with it may increase the risk for asthma disease in children and adults.

 
Keyword(s): CESAREAN SECTION, MODE OF DELIVERY, ASTHMA
 
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