Paper Information

Title: 

THE MEDICATIONS MOST COMMONLY INVOLVED IN DRUG-DRUG INTERACTIONS IN MASHHAD

Type: POSTER
Author(s): TAHERI EHSAN*,AFSHARI REZA,NAZEMIAN L.
 
 *MEDICAL TOXICOLOGY RESEARCH CENTRE, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Medication errors are an important problem, but little is known about the types of medications involved in errors. Interactions may affect pharmacokinetics and pharmacodynamic, which in turn play an important role for in vivo drug actions. They can lead to serious adverse events and economical problems. This study sought to describe the types of medications most frequently in drug-drug interactions in Mashhad. All paid prescriptions from insurance companies from 21 March 2006 (beginning of Iranian calendar) to 20 March 2008 were studied retrospectively. Data gathered from the Food and Drug Division of Mashhad University of Medical Sciences, Iran. Appropriate statistical analysis including student t-test and Chi-Square were performed using SPSS version 11.5. 4215 medication errors were reported. The medications most commonly involved in drug-drug interactions were Propranolol (3.7%), Gentamicin (3.5%), ASA (3.4%), Theophylline (3.2%), warfarin (2.3%), Carbamazepine (1.7%), Doxycycline Monohydrate (1.3%), Tetracycline (1.2%) and adult cold (1.2%). Quality improvement efforts should focus on the medications commonly involved in interactions and should continue to discourage or closely monitor the use of medications considered potentially inappropriate combinations.

 
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