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Paper Information

Title: 

THE EFECT OF ACYCLOVIR ON THE SPERMATOGENESIS BY ORALL ADMINISTRATION

Type: POSTER
Author(s): PARIVAR KAZEM,YAGHMAEI PARICHEHR,KHABIR M.A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Background and aim: acyclovir has been used to decrease the effect of HSV (herpes simplex viruses) in chicken pox or Bell ’s palsy and even for HIV. In this study the effect of acyclovir has been investigate on the histological changes of testis tissue and spermatogenesis.
Materials and methods: the experimental animals received 0.7 g/kg of body weight acyclovir orally by rubbing the drug on the lips of animals three times a day for 10 days sham group animals received vaseline only according to the experimental animals. Weeks after last treatment the animals were anesthized with ethyl ether. The testis were extrudes measured and then fixed in boins fixative for histological study. For statics analyses excel and Spss software’s were used.
Results: oral feeding of the drug did not show body and testicular change weight but significant decrease was observed in number of type a spermatogonia and primary spermatocytes in experimental groups compare to control and sham animals. Significant decrese in number of type a spermtogonia and primary sperm in excremental group compared to control and vehicle. There were no significant change in number of type b spermatogonia and sperm between groups. We observed an increase in thickness of tunica albuginea as well as a deacrease in number of sertolli cells in excremental groups.
Conclusion: the acyclovir as oral cream diminishes the reproductive system activity and should not be recommended for oral diseases.

 
Keyword(s): ACYCLOVIR, ORAL DIMISTATION, SPERMATOGENESIS
 
 
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