Paper Information

Title: 

EFFECT OF TAMOXIFEN ON LAYER UTERUS AND THE NUMBER OF OFFSPRINGS IN FEMALE WISTAR RATS

Type: POSTER
Author(s): KESHTMAND ZAHARA,ORYAN SHAHRBANOU,PARIVAR KAZEM,KESHTMAND MARZIEH
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Tamoxifen is a nonsteroidal antiestrogen which is rescribed for treatment of breast cancer. Some negative effects of this drug on the reproductive system have been observed. The aim of this study effect of Tamoxifen on the tissue uterus layers and the number of offspring’s of females in female Wistar rats were investigated. 100 rats (200-250 weighing) in this of study were used 60 ovarectomized rats and 40 intact female Wistar rats. Rats were divided into 5 groups (n=12,8 rat in each group),three group of rats gavaged with doses of 200,400 and 600μg/kg B.W Tamoxifen dissolved in solvent(ethanol 60% and physiological solution) for 30 days. The sham group was gavaged with solvent and control did not receive solvent and drug. On days 1and 30 after the end of treatment, 6 ovarectomized rat from each group selected randomly and sections of uterus stained with H&E method were investigated histological and also 4 intact female rat from each group with male rats mate and the number of offspring’s of them determined. Tukey test, one-way ANOVA and software SPSS11 were used for data analysis.
In the first sampling the thickness of uterus.
layers (perimetrium, myometrium, endometrium) and the number of offspring’s in experimental groups decreased compared with control (p<0.001). In the second sampling the thickness of layers uterus and the number of offspring’s in experimental groups increased compared with first sampling.
These finding suggest Tamoxifen decreases the fertilization ability and has negative effects on uterus layers and the number of offspring’s in female Wistar rats. The negative effects of Tamoxifen on uterus layers and of offspring’s is abolished with time elapsed.

 
Keyword(s): TAMOXIFEN, LAYERS UTERUS, OFFSPRING , RAT
 
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