Paper Information

Title: 

ANTIOXIDANT ROLE OF SUPEROXIDE DISMUTASE IN REDUCED BONE MASS DENSITY

Type: POSTER
Author(s): SADEGHI NAFISEH,OVEYSI M.R.,JANAT B.,HAJI MAHMOUDI MANAN,RASTGARI P.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Osteoporosis is a kind of metabolic disease with bone density reduction and susceptibility to deformity and breakage. Some studies show that osteoblasts can create some inter-cellular free radicals that lead to cell death. Superoxide dismutase (SOD) plays an essential role in cell defense against reactive oxygen metabolites. The purpose of this study was to investigate plasma SOD activity in Iranian women with osteoporosis. SOD activity was measured spectrophotometrically at 540 nm in 192 women. Participants were selected by inclusion and exclusion criteria among those who referred to Jamie Clinic in Tehran for BMD evaluation. Plasma activity of SOD (Mean±SD) was 1.72±0.79 g protein in the control group, 2.05±0.87 μg protein in the total patients (mild Osteopenia+severe Osteopenia and Osteoporosis) (T score<-1) and 2.32±0.91 μg protein in patients with severe Osteopenia and Osteoporosis (T score<-17). In this study, the plasma levels of SOD activity among Iranian osteoporotic women showed that plasma activity of SOD was significantly higher in the patients than in controls. Furthermore, this difference was more between the controls and patients with severe disease (T score<-1.7), than in the total patients. T score of femur adjusted with age and BMI showed a significant negative correlation with plasma activity of SOD in total patients.

 
Keyword(s): OSTEOPOROSIS, ANTIOXIDANT, SUPEROXIDE DISMUTASE ENZYME, PLASMA
 
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