Paper Information

Title: 

EFFECT OF SESAME OIL ON ERYTHROCYTE AND PLATELET INDICES OF DIABETIC RATS

Type: POSTER
Author(s): FATEMI TABATABAEI S.R.,HASANIZADEH SH.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

There are a lot of unsaturated fatty acids in sesame oil and some potent antioxidants, sesamin and sesaminol. Furthermore, it has been showed that sesame oil is useful in diabetic animals. As some hematological changes occur in diabetes and fatty acids composition can influence biomembrane characters, we investigated the effect of sesame oil on erythrocyte and platelet indices of diabetic rats in comparison to normal ones. Thirty-one month old male rats were divided to normal and streptozotocin induced diabetic groups. Two weeks after STZ injection each group were divided to three subgroups that fed with normal diet or diet supplemented with 10% sesame oil for 4 or 6 weeks. At the end of the 8th week, animals were sacrificed and blood was collected to assay erythrocyte and platelet indices and HbA1C. Diabetes significantly increased HbA1C, MCV and RDW, but decreased MCHC, Plt and PCT (packed platelet volume). Sesame oil improved HbA1C (p<0.001), MCV and PCT (p<0.05) in diabetic subgroups. Diabetes and sesame oil did not have any significant effect on RBC, Hb, PCV, MPV and PDW. Sesame oil may improve some hematological disturbances in diabetic animals that can be related to hyperglycemic control, fatty acid composition and/or antioxidant activity of this oil.

 
Keyword(s): SESAME OIL, DIABETES, PLATELET, ERYTHROCYTE
 
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