Paper Information

Title: 

CAPTOPRIL ENHANCES WOUND HEALING IN STREPTOZOTOCININDUCED DIABETIC RATS

Type: POSTER
Author(s): HAGHJOUY JAVANMARD SH.,ZANDIFAR A.R.,SOHRABI BEHESHTI S.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Healing of diabetic wounds still remains a critical medical problem. Angiogenesis is critical to wound repair. Impaired angiogenesis plays an essential role in the pathogenesis of diabetic wounds. We hypothesized that captopril would enhance wound healing by improving angiogenic function of endothelium. Eighteen male Wistar rats were separated in 3 groups. Twelve rats were rendered diabetic ten days prior to wounding by intraperitoneal streptozotocin injection (55 mg/kg) and were grouped randomly into 2 groups, six rats each. The animals of first group received 50 mg/kg captopril administered by gavage once daily. The animals of second group were treated by distilled water once daily, the third group was control and there was no intervention for them. The wound fluid VEGF was measured on the 5th day by ELISA. The period of treatment was 11 days. At the end of the period, wound skin specimens from all rats were collected in 10% buffered formalin and after the usual processing, 5 μm-thick sections were stained with haematoxylin and eosin. Sections were assessed under the light microscope and graded with histological score of wound healing. The first group that received Oral supplementation of captopril shows higher level of would fluid VEGF than diabetic rats of second group that received distilled water (942.79±342.7 vs. 139.55±38.7, p<0.05) while there was no significant difference between captopril group versus control group (1004.70±237.5). The histological scores of wound healing in first group was 9.8± 0.7 and 8±0.0 in the second group (p<0.05), and 10.5±0.8 in control group. There was no significant difference between captopril versus control group. These results suggest that captopril supplementation might be useful in restoring angiogenesis impairment associated with diabetic wound and wound healing.

 
Keyword(s): CAPTOPRIL, ANGIOGENESIS, DIABETES, WOUND HEALING
 
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