Paper Information

Title: 

INDUCTION OF HYPOTHYROIDISM CAUSES CHANGES IN HOMEOSTASIS OF COPPER (CU) AND ZINC (ZN) IN RAT

Type: POSTER
Author(s): YOUSEFVAND NAMDAR,SHIRZADI BEHFAR M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

The thyroid gland is one of the important endocrine glands of body that plays vital roles in the metabolism regulation and growth. Thyroid dysfunctions are considered as some of the most important endocrinopathies. Trace elements as Zinc (Zn) and Copper (Cu) play an important role in the proper performance of the most body organs. Thus, a small change causes main disruptions in the structure and function of the body. The aim of the present study was hypothyroid induction and investigation of its effects on change of two trace elements, Zn and Cu, in the serum. Twenty-one male rats weighting 135-145g were divided into three groups. The control group received drinking water; induced-hypothyroidism groups received two doses of propylthiouracil (PTU), 1- low dose treatment group, 1mg/100ml in drinking water and 2-high dose treatment group, 10mg/100ml in drinking water, for 60 days. At the end of experiment, the animals were sacrificed by deep anesthesia, serum samples were obtained and thyroid gland was removed. Serum levels of T3 and T4 were determined with radioimmunoassay and serum levels of Zn and Cu were measured with graphite atomic absorption spectrophotometer. Results showed that the serum level of T4 was reduced in treatment groups compared to control significantly. The serum levels of Zn compared to the control group were reduced but the serum levels of Cu increased. PTU, by induction of hypothyroidism and alteration in levels of T3 and T4, causes changes in homeostasis of Zn and Cu elements in the body.

 
Keyword(s): HYPOTHYROIDISM, PROPYLTHIOURACIL, ZINC (ZN), COPPER (CU), SERUM, RAT
 
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