Paper Information

Title: 

MEASUREMENT OF BLOOD HDL CHANGE IN RESPONSE TO DIFFERENT LEVELS OF PROGESTERONE IN PRESENCE OF ESTROGEN IN OVARIECTOMIZED RATS

Type: POSTER
Author(s): AZARMI Y.A.*,BABAEI HOSSEIN,REZAEI SAJAD,BABAPOUR V.,KHANDAGHI J.
 
 *FACULTY OF PHARMACY AND DRUG APPLIED RESEARCH CENTER, TABRIZ UNIVERSITY OF MEDICAL SCIENCES, TABRIZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Estrogen and progesterone as female sex hormones play important roles in regulation of metabolic and blood factors. By using these hormones in hormone therapy and as a conceptive drug, exact determination of different levels effects of these hormones is necessary. The effects of these hormones on blood HDL was studied in this article. This experimental-interference study was conducted on 70 female rats in 7 groups by 10 rats. Group1 was considered as sham operation. Ovariectomy was carried out on the 1st day and administration treatment begun on the 11th day and finally, sampling and measurement were done on the 31st day. Treatment hormone level: Group 1- shamp operation drug solvent; Group 2- Ovariectomy + drug solvent (control); Group 3- Ovariectomy + estrogen; Groups 4, 5, 6 and 7 were ovariectomized and in addition to receiving estrogen 50μg/kg, they received different levels of progesterone incrementally from half of base level up to twice base level. Administration of estrogen and progesterone in different levels reduced HDL level significantly compared to control group .Increase in progesterone doses in groups 5, 6 and 7 did not exert an additional reduction on these values and the level of reduction was equal to group 3, but a trivial reduction was observed. Estrogen reduces blood HDL level; there is no significant additional difference between different doses of progesterone.

 
Keyword(s): ESTROGEN, PROGESTERONE, HDL, OVARIECTOMY, RAT
 
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