Paper Information

Title: 

EFFECT OF ESTRADIOL REPLACEMENT ON VISCERAL FAT AND SERUM ADIPONECTIN LEVELS IN FEMALE RATS

Type: POSTER
Author(s): MAHDIZADEH RAHIMEH,DAMIRCHI A.,BABAEI PARVIN,ANSAR M.,SOLTANI BAHRAM
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Intra-abdominal fat accumulates with menopause and is linked with development of type 2 diabetes and cardiovascular disease. Whether hormone replacement therapy attenuates intra-abdominal fat and related risk factors is not clear. On the other hand, low plasma adiponectin levels are related to the development of atherosclerosis. The purpose of this study was to determine the effect of 17 b-estradiol replacement on visceral fat and serum adiponectin levels in ovariectomized (OVX) rats. Female Wistar rats, 11 weeks old, were divided into three groups: OVX rats receiving sesame oil (OVX-C, n=10), OVX rats receiving 17 b-estradiol valerate (30μg/kg bw, sc, 5 d/wk) replacement (OVX-ER, n=10) for 8 weeks and sham-operated control rats (SHAM, n = 10). After 8 weeks of intervention, the rats and visceral fat were weighed and serum adiponectin levels were measured by ELISA. Data were analyzed by one-way ANOVA and Tukey test in the level of a 0.05. After intervention, body weight (p<0.004) and visceral fat (p=0.014) were increased in OVX-C compared to SHAM. Body weight (p=0.031) decreased in OVX-ER compared to OVX-C. However, there were no significant differences in visceral fat and serum adiponectin concentration between OVX-C and OVX-ER groups. A marked reduction in body weight after 8 week 17 β-estradiol replacement does not affect adiponectin levels in OVX rats.

 
Keyword(s): OVARIECTOMY, 17 β-ESTRADIOL, BODY MASS INDEX, ADIPONECTIN
 
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