Paper Information

Title: 

SPASMODIC EFFECTS OF DUACUS CAROTA AQUEOUS EXTRACT ON NON-PREGNANT UTERUS IN RATS

Type: POSTER
Author(s): NIK RAFTAR O.A.B.,BAKHTIARIZADEH H.,AMIR ZARGAR A.,AHANGARPOUR A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Duacus carota from D. sativa Hoffm is a biennial grass-like plant. It has antioxidant properties. Carrot seeds cause abortion and prevent the pregnancy and facilitate delivery. It has effects similar to estrogen on the uterus and increases milk ejection and renders mild menstruation. The aim of this study was to investigate the effect of Daucus carota extract on the uterus contraction. A piece (1.5cm) of virgin adult rat uterus was mounted in an organ bath containing dejalon solution (29oC, pH 7.3-7.4), bubbled with oxygen. Uterus contractility was recorded isometrically under 1g initial tension. Uterus contractility was induced by KCl (60mM) and oxytocin (10mU/ml). KCl (60mM) induced uterus contraction and after 2min and during the plateau, the extract was added at 1-16 mg/ml cumulatively to the organ bath with 10 min intervals. In case of oxytocin, the affect of extract was studied noncumulatively. The effect of the extract was also investigated on contractions of uterus due to KCL and propranolol. The results were analyzed by ANOVA and post hoc LSD tests. The result indicated that KCl or OT enhances the uterus contractility. The uterus contraction induced by KCL and OT was also inhibited by Daucus carrota extract dose-dependently (p<0.05). Spasmolytic effect of extract was not affected by propranolol (1μM for 5 min) in KCl-induced contractions. Our results suggest that the spasmolytic effect of Daucus carota extract on rat uterus is mediated via voltage-dependent calcium channel. Aqueous extract of Duacus carota relaxed uterus contraction. Probably, activation of voltage-dependent calcium channel partially is involved in this process. b-adrenoreceptors are not involved in the spasmolytic effect of the extract.

 
Keyword(s): DUACUS CAROTA, PROPRANOLOL, OXYTOCIN, UTERUS
 
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