Paper Information

Title: 

EVALUATION OF URTICA DIOICA LEAF EXTRACT ON LIPID PROFILE IN FRUCTOSEINDUCED DIABETES IN FEMALE RATS

Type: POSTER
Author(s): MOHAMMADIAN MARYAM*,AHANGARPOUR A.,DIANAT MAHIN
 
 *DEPARTMENT OF PHYSIOLOGY, PHYSIOLOGY RESEARCH CENTER & DIABETES RESEARCH CENTER, SCHOOL OF MEDICINE, JUNDISHAPOUR MEDICAL SCIENCES UNIVERSITY OF AHWAZ, AHWAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Diabetes mellitus is a condition that occurs when the body cannot use glucose normally. Regardless of blood sugar control, diabetic patients tend to have increased triglyceride, decreased HDL, and sometimes increased LDL levels. Urtica dioica is recommended by ancient medical texts for the treatment of high blood sugar. This study aimed to evaluate the effect of Urtica dioica extract on lipid profile in a model of fructose induced diabetes. 40 adult male Wistar rats weighting 200-250g were used. Extraction of Urtica dioica was carried out by maceration method (60% alcohol). One group was considered as control group and other animals, after ingesting 10%fructose in drinking water for 6 weeks, were randomly divided into 4 groups: fructose-induced (sham), hydroalcoholic extract (50, 100 and 200 mg/kg) of Urtica dioica. 24 hours after the last ip injection, blood was collected from heart; serum was separated and triglyceride (TG), total cholesterol, Low-density-lipoprotein (LDL) cholesterol, HDL-cholesterol (HDL-C) and VLDL-cholesterol (VLDL-C) in serum were determined. Urtica dioica (50 mg/kg) increased TG and VLDL-C in comparison to control and sham groups. Also in this group, HDL-C decreased in comparison to control and (200 mg/kg) groups. When model of fructose rats were treated with low dose hydro-alcoholic extract of Urtica dioica, VLDL production in the liver was increased, leading to hypertriglyceridemia and consequently a low HDL-C level. Thus, until complete research, Urtica dioica extract is not recommended for decreasing the activity of lipid profile.

 
Keyword(s): URTICA DIOICA, LIPID PROFILE, FRUCTOSE
 
Yearly Visit 17   tarjomyar
 
Latest on Blog
Enter SID Blog