Paper Information

Title: 

EFFECT OF NEONATAL HYPOTHYROIDISM ON MORPHOLOGY OF PANCREATIC ISLETS IN ADULT MALE RATS

Type: POSTER
Author(s): FARAAHANI HAMID,ZAHEDIASL S.*,ROGHANI MEHRDAD,GHASEMI ASGHAR
 
 *ENDOCRINE PHYSIOLOGY LABORATORY, ENDOCRINE RESEARCH CENTRE, RESEARCH INSTITUTE FOR ENDOCRINE SCIENCES, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Growth retardation during neonatal life reflects on most tissues. The aim of this study was to investigate the effects of neonatal hypothyroidism on morphology of the pancreas during adulthood. Wistar rats were used in this study. After delivery, neonates were divided in two groups, neonatal hypothyroid (NH) and control (C). Propylthiouracil was administered to the NH group in the drinking water of their mothers until the end of wean (200ppm), while the C group consumed tap water. Weight and survival of neonates were recorded. The adult male rats were anesthetized, pancreas was removed and staining was performed by Gomori method. The cells in islets were counted under light microscope (400 X Magnification) and periphery of islets was measured by image tool-3 software. Plasma thyroid hormone levels of the NH group was significantly (p<0.05) lower than the C group, but not at the adulthood. Weight of the NH group was lower (p<0.05) than the C group throughout the study except at birth and after 3.5 month of life. Mortality of the NH group (42%) was significantly (p<0.05) higher than the C group (3%). Periphery of islets (504±38μm), and average numbers of the islets cells (109±11) in the NH group were significantly (p<0.05) lower compared to the C group (667±51μm) and (141±13) respectively. The neonatal hypothyroidism alters morphology of pancreas in the adult male rats and it may affect insulin secretion and glucose tolerance.

 
Keyword(s): NEONATAL HYPOTHYROIDISM, PANCREAS, CATCH UP GROWTH, SURVIVAL, RAT
 
Yearly Visit 7   tarjomyar
 
Latest on Blog
Enter SID Blog